Delle numerosissime pubblicazioni prodotte da tutti i ricercatori che hanno operato presso la Fondazione durante i 25 anni di attività, vengono riportati alcuni dei lavori che sulla base del numero di citazioni ricevute, hanno avuto maggiore impatto sul mondo scientifico.
01
Inflammatory changes in conjunctival scrapings after allergen provocation in humans.
Bonini Se, Bonini St, Vecchione A, Naim DM, Allansmith MR, Balsano F. J Allergy Clin Immunol. 1988; 82: 462-469
02
Human basophil degranulation triggered by very dilute antiserum against IgE. Evidence of non-reproducibility. Bonini S, Adriani E, Balsano F. Nature. 1988; 334: 559.
03
Antiplatelet treatment with ticlopidine in unstable angina-A controlled multicenter clinical-tiral. Balsano F, Rizzon P, Violi F, Scrutinio D, Cimminiello C, Aguglia F, Pasotti C, Rudelli G. Circulation 1990; 82: 17-26.
04
Selective killing of hepatitis B envelope antigen (HBenvAg)- specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes. Barnaba V, Franco A, Alberti A, Benvenuto R, Balsano F. Nature 1990; 345: 258-60.
05
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX. Natoli G, Avantaggiati M.L, Chirillo P, Costanzo A, Artini M, Balsano C, Levrero M. Molecular and Cellular Biology 1994; 14: 989-998.
06
Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Bonini Se, Lambiase A, Bonini St, Angelucci F, Magrini L, Manni L,Aloe L. Proc Natl Acad Sci. USA. 1996; 93: 10955-60.
07
Pathogenetic effector function of CD4+T helper 1 cells in hepatitis B virus transgenic mice. Franco A, Guidotti L, Hobbs M.V, Pasquetto V, Chisari F.V. J. Immunol. 1997; 159: 2001-08.
08
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett JR, Balsano C, Levrero M. Science 1997; 275: 200-203.
09
IKK-gamma is an essential regulatory subunit of the I kappa B kinase complex. Rothwarf DM, Zandi E, Natoli G, Karin M. Nature 1998; 395: 297-300.
10
Two new P73 splice variants, gamma and delta, with different transcriptional activity. De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, Levrero M, Melino G. Journal of Experimental Medicine 1998; 288: 1763-68.
11
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Sartorelli V, Puri PL, Hamamori Y, Ogryzko V, Chung G, Nakatani Y, Wang JY, Kedes L. Mol Cell. 1999; 4: 725-34.
12
Fine specificity and MHC restriction of trinitrophenyl (TNP) specific CTL. Franco A, Yokoyama T, Huynh D, Thomson C, Nathenson S.G, Grey H. J. Immunol. 1999;162: 3388-3394.
13
Epitope affinity for MHC class I determines helper requirement for CTL priming. Franco A, Tilly D.A, Gramaglia I, Croft M, Cipolla L, Meldal M, Grey H.M. Nature Immunology. 2000; 1:145-150.
14
Exposure to foodborne and orofecal microbes versus airborne viruses, in relation to atopy and allergic asthma: epidemiological study. Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S. Br Med J. 2000; 320: 412-17.
15
Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T cell cross-priming. Propato A., Cutrona G, Francavilla V, Ulivi M, E. Schiaffella E, Landt O, Dunbar R, Cerundolo V, Ferrarini M, Barnaba V. Nature Med. 2001; 7: 807-13.
16
p38-dependent marking of inflammatory genes for increased NFB recruitment. Saccani S, Pantano S, Natoli G. Nature Immunol. 2002; 3: 69-75. Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia. Paroli M, Accapezzato D, Francavilla V, Insalaco A, Plebani A, Balsano F, Barnaba V. Blood. 2002; 99: 2131-7.
17
Modulation of NF-kB activity by exchange of dimers. Saccani S, Pantano S, Natoli G. Molecular Cell 2003; 11: 1563- 74.
18
Physical and functional interaction between HCV core protein and the different p73 isoforms. Alisi A, Giambartolomei S, Cupelli F, Merlo P, Fontemaggi G, Spaziani A, Balsano C. Oncogene 2003; 22: 2573-80.
19
Modulation of tachykinin and cytokine release in patients with coronary disease undergoing percutaneous revascularization. Paroli M, Mariani P, Accapezzato D, D’Alessandro M, Di Russo C, Bifolco M, Sirinian MI, Fedele F, Bruno G, Sardella G. Clin Immunol. 2004;12: 78-84.
20
P38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Simone C, Forcales S.V, Hill D.A, Imbalzano A.N, Latella L, Puri PL. Nat. Genet. 2004; 36: 738-743.
21
Hepatic expansion of virus-specific regulatory CD8+ T cells in chronic hepatitis C virus infection. Accapezzato D, Francavilla V, Paroli M, Casciaro M, Chircu L.V, Abrignani S, Mondelli M.U, Barnaba V. J. Clin. Invest. 2004; 113: 963-72. Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas. Xu Y,Gendler S.J, Franco A. J. Exp. Med. 2004; 199: 707-716.
22
Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo. Accapezzato D, Visco V, Francavilla V, Molette C, Donato T, Paroli M, Mondelli M.U, Doria M, Torrisi M.R, Barnaba V. J. Exp. Med. 2005; 202:817-28.
23
Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells. Alisi A, Mele R, Spaziani A, Tavolaro S, Palescandolo E, Balsano C. J. Cell Physiol 2005; 205: 25-31.
24
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Minetti G.C,Colussi C, Adami R, Serra C, Mozzetta C, Parente V, Fortuni S, Straino S, SampaolesiM, Di Padova M, Illi B, Gallinari P, Steinkühler C, Capogrossi M.C, Sartorelli V, Bottinelli R, Gaetano C, Puri P.L. Nature Medicine 2006; 12: 1147-50.
25
TACI-BLyS signaling via B cell-dendritic cell cooperation is required for naïve CD8+ T-cell priming in vivo. Diaz-de-Durana Y, Mantchev G.T, Bram R.J, Franco A. Blood. 2006;107: 594-601.
26
Role of p38MAPK and PKR in HCV core-dependent nuclear delocalization of cyclin B1. Spaziani A, Alisi A, Sanna D, Balsano.C. JBC 2006; 281: 10983-89.
27
Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Rawson P.M, Molette C, Videtta M, Altieri L, Franceschini D, Donato T, Finocchi L, Propato A, Paroli M, Meloni F, Mastroianni C.M, d’Ettorre G, Sidney J, Sette A, Barnaba V. Nat. Med. 2007; 13: 1431-39.
28
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G. Cell 2007; 130: 1083-94.
29
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. Franceschini D, Paroli M, Francavilla V, Videtta M, Morrone S, Labbadia G, Cerino A, Mondelli M.U, Barnaba V. J Clin Invest. 2009; 119: 551-64.
30
Functions and therapeutic value of Focal Adhesion Kinase signaling during hepatocellular carcinoma development and progression. Alisi A, Balsano C. Hepatology 2010; 51: 1092-93.
31
Memory T cells and peripheral T cell clones in acute Kawasaki disease. Franco A, Shimizu C, Tremoulet A.H, Burns J.C. Autoimmunity. 2010; 43: 317-324
32
Hepatitis C virus and alcohol: same mitotic targets but different signalling pathways. Alisi A, Ghidinelli M, Zerbini A, Missale G, Balsano C. J. of Hepatology 2011; 54: 956-963.
33
Polyfunctional Type-1, -2, and -17 CD8+ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection. Franceschini D, Del Porto P, Piconese S, Trella E, Accapezzato D, Paroli M, Morrone S, Piccolella E, Spada E, Mele A, Sidney J, Sette A, Barnaba V. Plos Pathog. 2012: 10.1371/journal.ppat.1002759.
34
Clinical use of biologics in vasculitis syndromes. Paroli M. Biologics. 2012; 6: 371-8
35
Latent enhancers activated by stimulation in differentiated cells. Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G. Cell. 2013;152: 57-71.
36
Antonucci L, Porcu C, Timperi E, Santini SJ, Iannucci G, Balsano C. Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity. J Immunol Res. 2020;2020:4570219. (https://www.hindawi.com/journals/jir/2020/4570219/)
37
Oleuropein overrides liver damage in steatotic mice. Santini, S.J.,Porcu, C.,Tarantino, G.,Amicarelli, F.,Balsano, C.Journal of Functional Foods.2020;65,103756 (https://www.sciencedirect.com/science/article/pii S1756464619306802)
38
The application of artificial intelligence in hepatology: A systematic review. Balsano C, Alisi A, Brunetto MR, Invernizzi P, Burra P, Piscaglia F; Special Interest Group (SIG) Artificial Intelligence and Liver Diseases; Italian Association for the Study of the Liver (AISF). Dig Liver Dis. 2022;54(3):299-308.
(https://www.sciencedirect.com/science/article/pii/S1590865821003170?via%3Dihub)
39
Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage. Santini SJ, Tarantino G, Iezzi A, Alisi A, Balsano C. Nutr Metab (Lond). 2022;11;19(1):9.
(https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00641-z)
40
Fall of viral and bacterial pneumonia hospitalizations following COVID-19 pandemic mitigation strategies: a central Italian Region retrospective study. Clemente I, Santini SJ, Vittorini P, Pallotta E, Sinatti G, Fontana A, Mammarella L, Rancitelli E, Balsano C. Intern Emerg Med. 2023;18(4):1181-1189 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904871/?report=reader)
41
Sarcopenia, a condition shared by various diseases: can we alleviate or delay the progression? Tarantino G, Sinatti G, Citro V, Santini SJ, Balsano C. Intern Emerg Med. 2023 (https://link.springer.com/article/10.1007/s11739-023-03339-z#citeas)